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DeCS
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Descriptor English:
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Fusion Proteins, bcr-abl
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Descriptor Spanish:
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Proteínas de Fusión bcr-abl
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Descriptor Portuguese:
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Proteínas de Fusão bcr-abl
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Synonyms English:
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Oncogene Protein p190(bcr-abl)
Oncogene Protein p210(bcr-abl)
bcr-abl Fusion Proteins
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Tree Number:
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D12.776.602.500.500.100
D12.776.624.100
D12.776.624.664.500.100
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Definition English:
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Translation products of a fusion mRNA derived from the breakpoint cluster region (bcr) gene and a cellular abl (c-abl) gene translocated to chromosome 22. The p210(bcr-abl) fusion protein is found in patients with chronic myelogenous leukemia. The p190(bcr-abl) fusion protein is found in patients with acute lymphocytic leukemia. The activation of human c-abl by chromosomal translocation is essentially the same as the activation of murine c-abl by viral translocation in Abelson murine leukemia virus. |
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Indexing Annotation English:
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IM; found in various leukemias: coord IM with specific leukemia (IM); /drug eff /ultrastruct permitted
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See Related English:
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Philadelphia Chromosome
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History Note English:
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91; was BCR-ABL FUSION PROTEINS 1990
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Allowable Qualifiers English:
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Record Number:
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29237
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Unique Identifier:
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D016044
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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